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CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells
S J Teh1, N Killeen, A Tarakhovsky
1Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Blood
|February 15, 1997
Summary
The absence of CD2 glycoprotein enhances T-cell selection but impairs T-lymphocyte immune responses. This suggests CD2 plays a dual role in T-cell development and function.
Area of Science:
- Immunology
- Cell Biology
Background:
- The CD2 glycoprotein is involved in regulating T-cell activation.
- Its precise role in T-lymphocyte development and immune responses requires further investigation.
Purpose of the Study:
- To investigate the function of CD2 in T-lymphocyte development and immune responses.
- To analyze the impact of CD2 absence on T-cell selection and function.
Main Methods:
- Analysis of two lines of CD2-null mice with distinct T-cell receptor (TCR) specificities.
- Assessment of thymocyte selection and T-cell proliferative responses and interferon-gamma production.
Main Results:
- Absence of CD2 promoted positive selection of T-cells, similar to CD5-null conditions.
- Compound CD2 and CD5 deficiency further enhanced positive selection.
- Lack of CD2 led to impaired proliferative responses and interferon-gamma production in T-lymphocytes.
Conclusions:
- Impaired sensitivity to selecting ligands due to CD2 absence may enhance positive selection efficiency for specific TCRs.
- CD2 exhibits a differential role in thymocyte selection versus mature T-cell immune responses.