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Related Experiment Videos

Persistent polyclonal B-cell lymphocytosis in identical twins

R Carr1, K Fishlock, E Matutes

  • 1Department of Haematology, St Thomas' Hospital, London.

British Journal of Haematology
|February 1, 1997
PubMed
Summary

Persistent polyclonal B-cell lymphocytosis, a rare syndrome, was observed in identical twins for the first time. This finding strongly supports a genetic basis for the condition.

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Area of Science:

  • Hematology
  • Immunology
  • Genetics

Background:

  • Persistent polyclonal B-cell lymphocytosis (PPBL) is an uncommon hematologic disorder.
  • Previous studies suggested a genetic predisposition linked to HLA-DR7 and EBV infection.

Observation:

  • This report details the first documented occurrence of PPBL in monozygotic twins.
  • The syndrome presents with lymphocytosis, atypical binucleated lymphocytes, splenomegaly, and elevated serum IgM.

Findings:

  • The co-occurrence in identical twins provides compelling evidence for a hereditary component in PPBL.
  • Associated factors include female predominance, prior Epstein-Barr virus (EBV) infection, and cigarette smoking.

Implications:

  • These findings underscore the importance of genetic factors in the etiology of PPBL.

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  • Further research into the genetic underpinnings of PPBL is warranted.