Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A distributed nonlinear model of lung tissue elasticity

G N Maksym1, J H Bates

  • 1Meakins-Christie Laboratories, Montreal, Quebec, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1997
PubMed
Summary

This study models lung tissue elasticity using collagen and elastin fiber properties. Findings reveal inverse power laws in fiber distributions, potentially explaining lung pressure-volume curve shapes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reactance and elastance as measures of small airways response to bronchodilator in asthma.

Journal of applied physiology (Bethesda, Md. : 1985)·2019
Same author

Increasing likelihood of advanced pulmonary tuberculosis at initial diagnosis in a low-incidence US state.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2018
Same author

Effects of airway tree asymmetry on the emergence and spatial persistence of ventilation defects.

Journal of applied physiology (Bethesda, Md. : 1985)·2014
Same author

Blood volume in rats exposed to potential space cabin atmospheres. Hematologic responses to pure oxygen atmospheres at 190 mm. Hg total pressure.

Project report. USAF School of Aviation Medicine·2014
Same author

Fracture union following internal fixation in the HIV population.

Injury·2012
Same author

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

The European respiratory journal·2007

Area of Science:

  • Biomechanics
  • Materials Science
  • Pulmonary Medicine

Background:

  • Lung tissue elasticity is crucial for respiratory function.
  • Collagen and elastin are key structural components influencing lung mechanics.
  • Understanding their contribution to stress-strain properties is vital.

Purpose of the Study:

  • To develop a theoretical model linking lung tissue stress-strain properties to collagen and elastin.
  • To investigate the relationship between constituent fiber properties and overall lung elasticity.
  • To explain the mechanical basis of pressure-volume (PV) curve shapes in different lung conditions.

Main Methods:

  • Modeled lung tissue as parallel Hookean springs (elastin) and nonlinear string elements (collagen).
  • Developed analytical and numerical models incorporating distributed fiber properties.
  • Fit models to uniaxial stress-strain data from dog lung tissue and patient PV curves.

Main Results:

  • Distributed constituent properties accurately modeled nonlinear tissue elasticity.
  • Stop length and spring stiffness distributions followed inverse power laws.
  • Hypothesized fractal-like matrix structure underlies these power laws.
  • Mechanistically explained the shape factor K in PV curves based on collagen and elastin organization.

Conclusions:

  • The proposed model provides a mechanistic link between lung tissue microstructure and macroscopic elastic behavior.
  • Inverse power law distributions of collagen and elastin properties are characteristic of lung tissue.
  • This framework offers insights into altered lung mechanics in diseases like emphysema and fibrosis.

Related Experiment Videos