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Eglin-c prevents monocrotaline-induced ventilatory dysfunction
1Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1997
Summary
This study shows that eglin-c prevents monocrotaline-induced lung dysfunction in rats. Elastase inhibition protects against inflammation-mediated ventilatory abnormalities.
Area of Science:
- Pulmonary Medicine
- Biochemistry
- Toxicology
Background:
- Monocrotaline (MCT) exposure causes significant ventilatory dysfunction in rats.
- Endogenous elastase activity is implicated in inflammation-mediated lung injury.
Purpose of the Study:
- To investigate the role of elastase in monocrotaline (MCT)-induced ventilatory dysfunction.
- To evaluate the protective effects of the elastase inhibitor eglin-c against MCT-induced lung abnormalities.
Main Methods:
- Thirty-five rats were divided into control, MCT, eglin-c, and combination treatment groups.
- Eglin-c was administered intratracheally at different frequencies.
- MCT was administered via subcutaneous injection to induce lung injury.
Main Results:
- MCT-induced rats showed decreased dynamic respiratory compliance and maximal expiratory flow rates.
- Eglin-c treatment completely prevented these MCT-induced ventilatory deficits.
- Eglin-c alone did not alter ventilatory function compared to controls.
Conclusions:
- Eglin-c effectively prevents monocrotaline-induced ventilatory dysfunction in rats.
- Endogenous elastase plays a critical role in MCT-induced inflammation-mediated lung abnormalities.