Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eglin-c prevents monocrotaline-induced ventilatory dysfunction

Y L Lai1, K R Zhou

  • 1Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual blockade of IL-4 and IL-13 with dupilumab ameliorates sensorineural olfactory dysfunction in mice with eosinophilic sinonasal inflammation.

Rhinology·2024
Same author

[Research advances on the association between biomarkers and myocardial fibrosis].

Zhonghua xin xue guan bing za zhi·2018
Same author

Protein markers in the microcyst of the posteroventral cochlear nucleus of the gerbil.

Histology and histopathology·2007
Same author

Imaging findings of Castleman disease of the abdomen and pelvis.

Abdominal imaging·2007
Same author

Perceptions of dyspnea and helpful interventions during the advanced stage of lung cancer: Chinese patients' perspectives.

Cancer nursing·2007
Same author

Pancreatic adenocarcinoma: signs of vascular invasion determined by multi-detector row CT.

The British journal of radiology·2006

This study shows that eglin-c prevents monocrotaline-induced lung dysfunction in rats. Elastase inhibition protects against inflammation-mediated ventilatory abnormalities.

Area of Science:

  • Pulmonary Medicine
  • Biochemistry
  • Toxicology

Background:

  • Monocrotaline (MCT) exposure causes significant ventilatory dysfunction in rats.
  • Endogenous elastase activity is implicated in inflammation-mediated lung injury.

Purpose of the Study:

  • To investigate the role of elastase in monocrotaline (MCT)-induced ventilatory dysfunction.
  • To evaluate the protective effects of the elastase inhibitor eglin-c against MCT-induced lung abnormalities.

Main Methods:

  • Thirty-five rats were divided into control, MCT, eglin-c, and combination treatment groups.
  • Eglin-c was administered intratracheally at different frequencies.
  • MCT was administered via subcutaneous injection to induce lung injury.

Related Experiment Videos

Main Results:

  • MCT-induced rats showed decreased dynamic respiratory compliance and maximal expiratory flow rates.
  • Eglin-c treatment completely prevented these MCT-induced ventilatory deficits.
  • Eglin-c alone did not alter ventilatory function compared to controls.

Conclusions:

  • Eglin-c effectively prevents monocrotaline-induced ventilatory dysfunction in rats.
  • Endogenous elastase plays a critical role in MCT-induced inflammation-mediated lung abnormalities.