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Related Experiment Videos

A new polymer valve for mechanical circulatory support systems

S W Suh1, W G Kim, H C Kim

  • 1Department of Biomedical Engineering, Seoul National University, Korea.

The International Journal of Artificial Organs
|December 1, 1996
PubMed
Summary

A novel, low-cost artificial heart valve made from segmented polyurethane (SPU) demonstrates superior hydrodynamic performance compared to mechanical valves. This SPU valve showed excellent in vivo results in ventricular assist devices (VADs), with no complications or adverse effects observed.

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Engineering
  • Medical Device Development

Background:

  • Mechanical circulatory support systems (MCSS) often rely on artificial heart valves.
  • Existing mechanical valves can have limitations, driving the need for improved alternatives.
  • Segmented polyurethane (SPU) offers potential for fabricating advanced biomedical devices.

Purpose of the Study:

  • To develop and evaluate a new, low-cost artificial heart valve using SPU.
  • To compare the hydrodynamic performance of the SPU valve against a standard mechanical valve.
  • To assess the in vivo performance and biocompatibility of the SPU valve in a VAD system.

Main Methods:

  • Fabrication of an SPU artificial heart valve with a unique frame and membrane design.

Related Experiment Videos

  • Hydrodynamic performance testing using a mock circulatory system, comparing against the Björk-Shiley mechanical valve.
  • In vivo implantation and evaluation of the SPU valve within a ventricular assist device (VAD) in mongrel dogs.

    • Main Results:

    • The SPU valve exhibited superior hydrodynamic performance compared to the Björk-Shiley mechanical valve.
    • In vivo testing in VADs showed no valve-related complications during experiments.
    • Postmortem examinations revealed no thrombus formation on the SPU valve or embolic events.

    Conclusions:

    • The developed SPU artificial heart valve is a promising, low-cost alternative for MCSS.
    • Its superior hydrodynamic properties and excellent biocompatibility support its potential clinical application.
    • This SPU valve could be a valuable component for future VAD and total artificial heart (TAH) designs.