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New radiopaque polyHEMA-based hydrogel particles

D Horák1, M Metalová, F Rypácek

  • 1Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Journal of Biomedical Materials Research
|February 1, 1997
PubMed
Summary

New iodine-containing polymeric hydrogel particles were synthesized for X-ray imaging. These radiopaque particles exhibit significant swelling when their acid groups are converted to the Na+ form, with higher MABA content leading to increased swelling.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Radiopaque Materials

Background:

  • Development of novel radiopaque materials is crucial for advanced medical imaging.
  • Hydrogel particles offer versatile platforms for drug delivery and imaging applications.
  • Iodine-containing polymers are effective contrast agents due to high atomic number.

Purpose of the Study:

  • To synthesize novel iodine-containing polymeric hydrogel particles.
  • To evaluate the radiopacity and swelling behavior of these particles.
  • To explore the influence of MABA content on particle properties.

Main Methods:

  • Suspension radical copolymerization of HEMA, MABA, and EDMA.
  • Use of inert diluents (cyclohexanol, 1-dodecanol) to create porosity.

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  • Characterization of radiopacity and equilibrium swelling behavior.

    • Main Results:

    • Successfully prepared iodine-containing hydrogel particles with tunable iodine content.
    • Particles with 27 wt% iodine demonstrated sufficient radiopacity for X-ray imaging.
    • Equilibrium swelling significantly increased upon conversion of MABA acid groups to Na+ form.
    • Higher MABA content correlated with enhanced swelling in the Na+ form.

    Conclusions:

    • The synthesized polymeric hydrogel particles are promising for radiopaque applications.
    • The swelling behavior can be effectively modulated by ion exchange, suggesting potential for controlled release applications.
    • These findings contribute to the development of advanced imaging agents and functional hydrogels.