Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental peri-implant tissue breakdown around hydroxyapatite-coated implants

O Hanisch1, C A Cortella, M M Boskovic

  • 1Center for Prosthodonotics and Implant Dentistry, Loma Linda University, CA, USA.

Journal of Periodontology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Viruses in the Pathogenesis of Periodontitis.

Journal of periodontal research·2025
Same author

The palliative management of non-islet cell tumour hypoglycaemia with glucocorticoids and somatostatin analogues in an unresectable hepatocellular carcinoma.

Annals of the Royal College of Surgeons of England·2022
Same author

Impact of untreated sewage and thermal effluent discharges on the air-sea CO<sub>2</sub> fluxes in a highly urbanized tropical coastal region.

Marine pollution bulletin·2021
Same author

Human pituitary adenomas do not overexpress thec-erbB-2 oncoprotein.

Endocrine pathology·2020
Same author

Reversal of severe cognitive impairment following medical treatment of cystic invasive giant prolactinoma.

Endocrinology, diabetes & metabolism case reports·2016
Same author

De novo deletions and duplications of 17q25.3 cause susceptibility to cardiovascular malformations.

Orphanet journal of rare diseases·2015

Experimental plaque accumulation around hydroxyapatite-coated implants in non-human primates led to peri-implant tissue breakdown. The study highlights a preclinical model for peri-implantitis, crucial for developing new treatments.

Area of Science:

  • Dental Implantology
  • Periodontology
  • Microbiology

Background:

  • Peri-implant tissue breakdown is a significant concern following dental implant placement.
  • Hydroxyapatite (HA)-coated implants are widely used, but understanding their response to plaque accumulation is critical.

Purpose of the Study:

  • To investigate experimental peri-implant tissue breakdown around HA-coated titanium implants in a non-human primate model.
  • To analyze the associated submucosal microbiota changes during plaque accumulation and resolution.

Main Methods:

  • Thirty-two HA-coated implants were placed in Macaca mulatta monkeys.
  • Plaque accumulation was induced using cotton ligatures around healing abutments.
  • Clinical, radiographic, and submucosal microbial samples were collected at various time points.

Related Experiment Videos

Main Results:

  • Plaque accumulation significantly increased modified plaque index, gingival index, and bleeding on probing.
  • Progressive probing depth and clinical attachment level increases were observed.
  • Submucosal microbiota shifted to include Gram-negative anaerobic rods, including Porphyromonas gingivalis, resembling human peri-implantitis.

Conclusions:

  • Ligature-induced plaque accumulation is a precursor to peri-implant tissue breakdown around HA-coated implants.
  • The observed microbiota changes mimic those found in human peri-implantitis and destructive periodontal disease.
  • This preclinical model is valuable for studying interventions for peri-implantitis and bone regeneration.