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Related Experiment Videos

Drug discovery using receptors that modulate gene expression

P Lamb1, J Rosen

  • 1Ligand Pharmaceuticals San Diego California 92121, USA.

Journal of Receptor and Signal Transduction Research
|January 1, 1997
PubMed
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Cytokines and steroid hormones regulate gene expression via transcription factors. High-throughput assays screen for compounds affecting these pathways, aiding drug discovery.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Drug Discovery

Background:

  • Cytokines and steroid hormones rapidly regulate cellular gene expression.
  • This regulation involves activating latent transcription factors that bind to specific gene promoter sequences.

Purpose of the Study:

  • To discuss high-throughput assay systems for screening compounds.
  • To explore opportunities for discovering novel agonists and antagonists.

Main Methods:

  • Development of high-throughput assay systems.
  • Utilizing molecular understanding of transcriptional regulation processes.

Main Results:

  • Assay systems are effective for screening agonists and antagonists.

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  • These systems facilitate the discovery of novel compounds.

    • Conclusions:

    • High-throughput assays offer significant opportunities for identifying selective modulators.
    • Advancements in understanding transcriptional regulation drive drug discovery efforts.