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Body iron stores decrease in boys during pubertal development: the transferrin receptor-ferritin ratio as an

R Anttila¹, J D Cook, M A Siimes

¹Children's Hospital, University of Helsinki, Finland.

Pediatric Research

|February 1, 1997

Summary

Serum transferrin receptor and ferritin levels can indicate iron status in growing boys. The transferrin receptor-ferritin ratio effectively tracks iron deficiency during puberty, responding well to iron therapy.

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Area of Science:

Pediatric Hematology
Nutritional Biochemistry
Iron Metabolism

Background:

Serum transferrin receptor (sTfR) indicates tissue iron deficiency and erythropoiesis.
Serum ferritin reflects total body iron stores.
Iron status is crucial during puberty due to growth and increased demands.

Purpose of the Study:

To evaluate iron status in healthy boys during puberty using sTfR and the sTfR-ferritin ratio.
To assess the correlation between these markers and pubertal development.
To determine the responsiveness of these markers to iron therapy.

Main Methods:

Longitudinal study of 57 healthy prepubertal/early pubertal boys over 24 months.
Regular monitoring of hemoglobin, mean corpuscular volume, sTfR, ferritin, and sTfR-ferritin ratio.

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Correlation analysis with genital development and response to iron therapy.

Main Results:

Significant changes observed in Hb, MCV, sTfR, ferritin, and sTfR-ferritin ratio over 24 months.
Increased prevalence of elevated sTfR or low ferritin, and simultaneous abnormalities.
sTfR-ferritin ratio showed a 4.5-fold increase, correlating with genital development.
Iron therapy normalized the sTfR-ferritin ratio, confirming its dependence on iron status.

Conclusions:

The sTfR-ferritin ratio is a sensitive indicator of iron status changes during puberty.
This ratio is more responsive to iron status than to erythropoiesis rate.
Monitoring sTfR and ferritin is valuable for assessing iron sufficiency in adolescents.