Related Experiment Video
Updated: Aug 9, 2026

07:34
FISH for Pre-implantation Genetic Diagnosis
Published on: February 24, 2011
Molecular cytogenetics of t(12;21) (p13;q22)
O A Bernard1, S P Romana, H Poirel
1U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Leukemia & Lymphoma
|November 1, 1996
Abstract:
The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL-AML1, is transcribed from the der(21) and encodes the 336 NH2 aminoacics of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated with loss of the normal, untranslocated TEL allele. These various aspects are presented here.

