Granulocyte dysplasia and dysfunction, and CD11/CD18 defects in myelodysplastic syndromes
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Updated: Oct 9, 2026
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
A Mazzone1, C Porta, G Fossati
1Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia, I.R.C.C.S. Policlinico San Matteo, Italy.
Abstract:
In myelodysplastic syndromes (MDS), dysplastic changes in neutrophils are a common feature reflecting the total degree of bone marrow dysplasia. Furthermore, granulocyte function is abnormal, so that a high risk of life-threatening infections has been documented. In this review we shall focus on the defects of both granulocytes and their CD11b/CD18 glycoprotein complex, which regulate granulocyte adherence, locomotion, diapedesis and migration into inflammatory sites, in patients suffering from primary MDS. The defective surface membrane glycoprotein expression of myelodysplastic phagocytes is not only a useful diagnostic tool, but also a powerful prognostic one, since MDS patients with such defects present both an increased susceptibility to infections and a decreased survival. Moreover, the administration of colony-stimulating factors is known to be able to elicit long-lasting improvement in neutrophil count, CD11b/CD18 expression and function, marrow myeloid maturation, and possibly to decrease bacterial infections in MDS patients.
Insights
Myelodysplastic syndromes (MDS) involve neutrophil defects, increasing infection risk. Addressing these granulocyte and CD11b/CD18 glycoprotein issues may improve outcomes and survival in MDS patients.
Area of Science:
- Hematology
- Immunology
Background:
- Myelodysplastic syndromes (MDS) are characterized by dysplastic neutrophils, indicating overall bone marrow dysplasia.
- Abnormal granulocyte function in MDS leads to a high risk of severe infections.
Purpose of the Study:
- To review defects in granulocytes and the CD11b/CD18 glycoprotein complex in primary MDS.
- To explore the diagnostic and prognostic significance of these defects.
Main Methods:
- Focus on reviewing literature concerning granulocyte and CD11b/CD18 glycoprotein defects in MDS patients.
- Analysis of surface membrane glycoprotein expression in myelodysplastic phagocytes.
Main Results:
- Defective surface membrane glycoprotein expression in myelodysplastic phagocytes serves as a diagnostic and prognostic marker.
- MDS patients with these defects exhibit increased infection susceptibility and reduced survival.
Conclusions:
- Defects in neutrophils and CD11b/CD18 glycoprotein complex are key features of MDS.
- Colony-stimulating factors may improve neutrophil function, count, and potentially reduce infections in MDS patients.
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