Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neonatal lupus syndromes

C E Tseng¹, J P Buyon

¹Department of Medicine, New York University School of Medicine, New York, USA.

Rheumatic Diseases Clinics of North America

|February 1, 1997

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Salivary dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus.

Journal of autoimmunity·2019

Same author

Keeping upbeat to prevent the heartbreak of anti-Ro/SSA pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019

Same author

Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.

AJNR. American journal of neuroradiology·2017

Same author

Autoimmune congenital heart block: complex and unusual situations.

Lupus·2016

Same author

Efficacy and safety of subcutaneous tabalumab, a monoclonal antibody to B-cell activating factor, in patients with systemic lupus erythematosus: results from ILLUMINATE-2, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study.

Annals of the rheumatic diseases·2015

Same author

Anti-C1q antibodies in systemic lupus erythematosus.

Lupus·2014

Same journal

Rheumatology at the Threshold of Artificial Intelligence.

Rheumatic diseases clinics of North America·2026

Same journal

Foreword.

Rheumatic diseases clinics of North America·2026

Same journal

Artificial Intelligence Regulation in the United States: Current Landscape and Implications for Rheumatology.

Rheumatic diseases clinics of North America·2026

Same journal

The Role of Artificial Intelligence in Medical Education and Training: Implications for Rheumatology.

Rheumatic diseases clinics of North America·2026

Same journal

Sources of Bias in Clinical Artificial Intelligence and Applications in Rheumatology.

Rheumatic diseases clinics of North America·2026

Same journal

Toward Bridging the Gap from Artificial Intelligence in Clinical Research to Clinical Practice in Rheumatology: The Mayo Experience.

Rheumatic diseases clinics of North America·2026

See all related articles

Maternal autoantibodies targeting SSA/Ro and SSB/La ribonucleoproteins can cause congenital heart block and neonatal lupus syndromes in infants. Early diagnosis and management are crucial for affected newborns.

Area of Science:

Immunology
Perinatology
Rheumatology

Background:

Congenital heart block serves as a model for passively acquired autoimmunity.
Maternal autoantibodies crossing the placenta can affect fetal development.
Neonatal lupus syndromes encompass congenital heart block and other fetal abnormalities linked to maternal autoantibodies.

Purpose of the Study:

To review the histopathology of neonatal lupus syndromes.
To discuss SSA/Ro-SSB/La antigen-antibody systems in relation to these syndromes.
To outline clinical manifestations, diagnosis, and management strategies.

Main Methods:

Review of existing literature on congenital heart block and neonatal lupus.
Analysis of SSA/Ro-SSB/La antigen-antibody systems.

Related Experiment Videos

Compilation of clinical, immunogenetic, and histopathological data.

Main Results:

Maternal immune abnormalities lead to autoantibodies targeting SSA/Ro and SSB/La ribonucleoproteins.
These autoantibodies cross the placenta, potentially harming the fetus.
Neonatal abnormalities including skin, liver, and blood issues are associated with these antibodies.

Conclusions:

Congenital heart block and neonatal lupus syndromes are linked to maternal SSA/Ro-SSB/La autoantibodies.
Understanding the immunogenetics and clinical spectrum is key for diagnosis.
Effective management strategies are essential for affected neonates.