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Related Experiment Videos

The newly discovered non A-E hepatitis viruses

S Songsivilai1, T Dharakul

  • 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sissv@mahidol ac.th

The Southeast Asian Journal of Tropical Medicine and Public Health
|March 1, 1996
PubMed
Summary

Four new hepatitis viruses (HGV and GBV agents) were discovered, closely related to HCV. These viruses are prevalent in blood donors, transmitted parenterally, and can cause chronic infections, including cirrhosis.

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Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Background:

  • Discovery of novel hepatitis viruses is crucial for understanding liver disease.
  • Hepatitis C virus (HCV) and hepatitis B virus (HBV) are well-established causes of chronic liver disease.
  • Emerging infectious agents pose ongoing public health challenges.

Purpose of the Study:

  • To report the discovery and initial characterization of four new hepatitis viruses.
  • To investigate the prevalence and transmission of these novel agents.
  • To explore the clinical significance and potential treatment of infections caused by these viruses.

Main Methods:

  • Molecular biological techniques were employed to identify viral genomes.
  • Patients with non-A-E hepatitis lacking markers for known hepatitis viruses were studied.

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  • Prevalence studies were conducted in blood donor populations across multiple continents.

    • Main Results:

    • Four new hepatitis viruses, HGV and GBV agents (GBV-A, GBV-B, GBV-C), were identified.
    • These viruses belong to the Flaviviridae family and are related to HCV.
    • High prevalence was observed in blood donors globally; parenteral transmission and chronic infection leading to cirrhosis are common.
    • Coinfection with HCV and/or HBV occurs, and some cases respond to interferon therapy.

    Conclusions:

    • The discovery of HGV and GBV agents expands the spectrum of known hepatitis viruses.
    • These novel viruses represent a significant public health concern due to their high prevalence and potential for chronic liver disease.
    • Further research is needed to fully elucidate their clinical significance, transmission dynamics, and optimal management strategies.