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Ceftibuten concentrations in human tonsillar tissue

F Scaglione1, J P Pintucci, G Demartini

  • 1Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università Degli Studi di Milano, Italy.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|December 1, 1996
PubMed
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This study measured ceftibuten levels in tonsillar tissue after a single oral dose. High concentrations suggest a once-daily regimen may effectively treat tonsillitis and pharyngitis.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Tonsillitis and pharyngitis are common infections.
  • Effective antibiotic treatment requires adequate drug concentrations at the infection site.

Purpose of the Study:

  • To determine ceftibuten concentrations in human tonsillar tissue.
  • To evaluate the potential for a once-daily ceftibuten regimen for tonsillitis and pharyngitis.

Main Methods:

  • Subjects received a single 400 mg oral dose of ceftibuten.
  • Tonsillar tissue and serum samples were collected during tonsillectomy (2-24 hours post-dose).
  • Ceftibuten concentrations were measured using tissue and serum assays.

Main Results:

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  • Mean tonsillar tissue concentrations were 5.3 mg/g at 4.4 hours and 0.3 mg/g at 24.6 hours.
  • Mean serum concentrations were 7.42 mg/ml at 4.4 hours and 0.15 mg/ml at 24.6 hours.
  • The apparent half-life of ceftibuten in tonsillar tissue was 5.3 hours.

    • Conclusions:

    • Ceftibuten achieves significant concentrations in tonsillar tissue.
    • A once-daily dosing regimen of ceftibuten may be effective for treating tonsillitis and pharyngitis.