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Related Experiment Videos

Phasic craving for carbohydrate observed with citalopram

C D Bouwer1, B H Harvey

  • 1Department of Psychiatry, University of Stellenbosch Medical School, Tygerberg, Republic of South Africa.

International Clinical Psychopharmacology
|December 1, 1996
PubMed
Summary

Selective serotonin reuptake inhibitors (SSRIs) like citalopram can paradoxically increase carbohydrate craving and weight gain in some patients. This side effect impacts treatment compliance and requires consideration in depression management.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression.
  • Tricyclic antidepressants are known to cause carbohydrate craving and weight gain.
  • Carbohydrate craving is a significant, often overlooked, complication in depression treatment.

Purpose of the Study:

  • To investigate the association between citalopram, a SSRI, and carbohydrate craving.
  • To explore the potential mechanisms behind SSRI-induced carbohydrate craving and weight gain.
  • To assess the impact of this side effect on patient compliance.

Main Methods:

  • A cohort of 18 patients with mood disorders treated with citalopram was studied.
  • Mood and anxiety symptom rating scales were used to track patient status.

Related Experiment Videos

  • Observed changes in carbohydrate craving and weight were recorded.

    • Main Results:

    • Eight out of 18 patients experienced increased carbohydrate craving and weight gain after starting citalopram.
    • The carbohydrate craving presented in a phasic pattern.
    • Observed effects appeared paradoxical given serotonin's typical role in appetite regulation.

    Conclusions:

    • Citalopram may induce carbohydrate craving and weight gain in a subset of patients.
    • The receptor binding profile of citalopram might explain this adverse effect.
    • This SSRI side effect significantly influences patient acceptability and treatment adherence.