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The prion folding problem
P M Harrison1, P Bamborough, V Daggett
1University of California, Box Number 450, San Francisco, CA-94143, USA.
Current Opinion in Structural Biology
|February 1, 1997
Abstract:
Prion diseases are neurodegenerative disorders in which dramatic conformational change in the structure of the prion protein is the fundamental event. This structural transition involves the loss of substantial alpha-helical content and the acquisition of beta-sheet structure. A convergence of recent biological and structural studies argues that the mechanism underlying the prion diseases is truly unprecedented.