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Visualization of DNA Repair Proteins Interaction by Immunofluorescence
Published on: June 26, 2020
DNA-repair enzymes
1International Institute for Advanced Research, Central Research Laboratories, Matsushita Electric Industrial, 3-4 Hikari-dai, Seika, Kyoto 619-02, Japan. dmitry@crl.mei.co.jp
Abstract:
Recent crystallographic studies of DNA-repair enzymes have provided the structural basis for the recognition of damaged DNA. The results imply that flipping out of the base is a common and crucial event in DNA repair. Two classes of repair enzymes that recognize distinct types of damage may exist. DNA-repair enzymes that share similar folds and DNA binding motifs have been proposed to belong to a superfamily.
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