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Not just another Fab: the crystal structure of a TcR-MHC-peptide complex
1Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA. jardetz@tochtli. biochem.nwu.edu
Structure (London, England : 1993)
|February 15, 1997
Abstract:
The structure of a ternary complex formed between a T-cell receptor, a major histocompatibility complex (MHC) protein and a viral peptide provides new insights into the cellular immune response. The results provide a molecular basis for understanding the development of T cells and the reactions leading to transplant rejection and autoimmunity.