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Related Experiment Videos

Development of an implantable ventricular assist system

M P Macris1, S M Parnis, O H Frazier

  • 1Cullen Cardiovascular Research Laboratories, Department of Cardiovascular Surgical Research, Texas Heart Institute, Houston 77030, USA.

The Annals of Thoracic Surgery
|February 1, 1997
PubMed
Summary

The Jarvik 2000 ventricular assist system shows promise for long-term patient support. This implantable blood pump demonstrated feasibility in animal studies with no significant complications.

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Evaluation of myocardial function in patients with end-stage heart failure during support with the Jarvik 2000 left ventricular assist device.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Medical Technology

Background:

  • The Jarvik 2000 is an intraventricular axial-flow blood pump designed for implantation.
  • It utilizes a transcutaneous energy transfer system and internal batteries for power.

Purpose of the Study:

  • To describe the development progress of the Jarvik 2000 ventricular assist system.
  • To evaluate the feasibility and safety of the device in animal models.

Main Methods:

  • The system features a compact (25 cm3, 90 g) blood pump with internal electronics.
  • Power is supplied by internal and external polymer lithium ion batteries.
  • A brushless direct-current motor with redundant coil design ensures operational continuity.

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Main Results:

  • Seven calves were supported for an average of 107 days (40-162 days).
  • No physiological complications were observed; renal and hepatic functions remained normal.
  • Mean plasma free hemoglobin levels were low (mean, 6.3 mg/dL), and no device-related organ damage was found.

Conclusions:

  • The Jarvik 2000 ventricular assist system is feasible in animal subjects.
  • The device shows potential for long-term circulatory support in patients.