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Familial intracranial aneurysms

A Ronkainen1, J Hernesniemi, M Puranen

  • 1Department of Neurosurgery, University Hospital of Kuopio, Finland.

Lancet (London, England)
|February 8, 1997
PubMed
Summary
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First-degree relatives of individuals with intracranial aneurysms have a high prevalence of these conditions. The risk for close relatives is significantly elevated compared to the general population.

Area of Science:

  • Neurology
  • Genetics
  • Vascular Medicine

Background:

  • Intracranial aneurysms (IAs) affect individuals and can aggregate within families.
  • Polycystic kidney disease (PKD) is a heritable disorder that has been anecdotally linked to IA aggregation.

Purpose of the Study:

  • To determine the prevalence of incidental intracranial aneurysms in first-degree relatives (aged ≥30 years) of IA patients.
  • To investigate if polycystic kidney disease contributes to the familial aggregation of intracranial aneurysms.

Main Methods:

  • Identified 91 families with multiple IA members from 1150 IA patients.
  • Utilized magnetic resonance angiography (MRA) for screening and conventional four-vessel angiography for confirmation.
  • Screened participants for polycystic kidneys using ultrasonography.

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Main Results:

  • Incidental aneurysms were found in 8.7% of first-degree relatives (aged ≥30 years) in families without PKD.
  • Two individuals with PKD in one family had incidental aneurysms.
  • The prevalence of incidental intracranial aneurysms in first-degree relatives was 8.7% (CI 6.2-11.7).

Conclusions:

  • Demonstrated a high prevalence of incidental intracranial aneurysms in first-degree relatives of IA patients.
  • Indicated a four-fold increased risk of intracranial aneurysms for close relatives compared to the general population.
  • Showed that families with polycystic kidney disease represent a small proportion of familial intracranial aneurysm cases.