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[Epinephrine stability in solutions for intra-ocular irrigations]
A C Gairard1, S Demirdjian, R Vasseur
1Service de Pharmacie-Pharmacologie, Hôtel-Dieu, Paris.
Journal Francais D'Ophtalmologie
|January 1, 1996
Summary
Epinephrine (a medication) remains stable in ocular irrigation solutions for up to two weeks when refrigerated or one month when frozen. This allows for centralized preparation and storage of ophthalmic irrigation solutions.
Area of Science:
- Ophthalmology
- Pharmacology
- Analytical Chemistry
Context:
- Epinephrine is utilized in ophthalmic surgery for ocular irrigation.
- The stability of epinephrine in aqueous solutions is influenced by environmental factors.
- Accurate quantification of epinephrine is crucial for safe and effective ophthalmic procedures.
Purpose:
- To assess the stability of diluted epinephrine in ocular irrigation solutions under various storage conditions.
- To determine the optimal storage duration and temperature for pre-prepared epinephrine irrigation bags.
- To evaluate the impact of thawing methods on epinephrine stability.
Summary:
- Epinephrine solutions (1 mg/L) demonstrated stability for 2 days at room temperature, 14 days at +4°C, and 35 days at -20°C.
- High-performance liquid chromatography (HPLC) with UV detection was used to analyze epinephrine stability.
- Microwave thawing did not negatively affect epinephrine stability in the tested solutions.
Impact:
- Findings support the centralized preparation and storage of epinephrine for ocular irrigation.
- Establishes practical guidelines for maintaining epinephrine efficacy in ophthalmic settings.
- Enhances the efficiency and safety of ophthalmic surgical procedures through reliable irrigation solutions.