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Waldenström's macroglobulinemia associated with glioblastoma. A case report
E Lamaida1, F Caputi, A Rapanà
1Neurosurgical Department, Ospedale S. Luca, Vallo della Lucania, Italie.
Abstract:
Waldenström Macroglobulinemia (WM) involves the Central Nervous System in about 10% of the affected patients, but only occasionally related clinical and histopathological changes have been considered. Most of the published papers focus on leptomeningeal lymphoplasmacytic infiltrates, even though the damage to the CNS results in a more variegated scenario. Association to a malignant neoplasm, usually of lymphoid series, is not uncommon, instead association with a glioblastoma is rare, and only 3 cases have been reported. Despite the rarity of this finding, the association Waldenström Macroglobulinemia-glioblastoma may not be coincidental. Probable etiopathological links are thereby discussed.
Insights
Waldenström Macroglobulinemia (WM) can affect the central nervous system (CNS). This rare association with glioblastoma warrants further investigation into potential etiopathological links.
Area of Science:
- Neuro-oncology
- Hematology
- Neuropathology
Background:
- Waldenström Macroglobulinemia (WM) is a rare lymphoproliferative disorder.
- Central Nervous System (CNS) involvement occurs in approximately 10% of WM patients.
- Leptomeningeal lymphoplasmacytic infiltrates are the most commonly reported CNS manifestation.
Observation:
- CNS involvement in WM presents a more complex clinical and histopathological picture than previously recognized.
- Co-occurrence of WM with glioblastoma is exceptionally rare, with only three prior cases documented.
- This case series explores the potential non-coincidental association between WM and glioblastoma.
Findings:
- The study discusses the potential etiopathological links between Waldenström Macroglobulinemia and glioblastoma.
- Analysis of rare co-occurrences suggests possible shared underlying mechanisms.
- Histopathological examination reveals a variegated CNS damage pattern beyond simple leptomeningeal infiltration.
Implications:
- Understanding these rare associations may offer new insights into CNS oncogenesis.
- Further research is needed to elucidate the shared pathways between WM and glioblastoma.
- This highlights the importance of considering diverse CNS pathologies in WM patients.