Related Experiment Videos
No evidence for an allelic association between schizophrenia and markers D22S278 and D22S283
N M Williams1, L A Jones, K C Murphy
1Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
American Journal of Medical Genetics
|February 21, 1997
Abstract:
We report a case control association study using markers D22S278 and D22S283 in 90 unrelated patients with DSMIII-R schizophrenia and 90 controls matched for ethnicity, age and sex. No differences between allele frequencies for either marker were observed when the two groups were compared (D22S278: chi 2 = 6.53, df = 7, P = 0.51; D22S283: chi 2 = 14.73, df = 15, P = 0.48). These findings fail to support previous work by others suggesting the presence of allelic association between the markers D22S278 and D22S283 and schizophrenia.