Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Translational control during early development

B Stebbins-Boaz1, J D Richter

  • 1Worcester Foundation for Biomedical Research, Shrewsbury, MA 01545, USA.

Critical Reviews in Eukaryotic Gene Expression
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis.

Oncogene·2015
Same author

Translational control of embryonic cell division by CPEB and maskin.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

New ways of initiating translation in eukaryotes.

Molecular and cellular biology·2001
Same author

Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.

Developmental cell·2001
Same author

CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.

Development (Cambridge, England)·2001
Same journal

PFKFB2-Induced Glycolysis and Ferroptosis in Diabetic Nephropathy by HIF-1α.

Critical reviews in eukaryotic gene expression·2026
Same journal

LncRNA MANCR Acts as a ceRNA to Sponge MicroRNA-20a-5p and Upregulate GCNT4 to Suppress Angiogenesis in Colorectal Cancer.

Critical reviews in eukaryotic gene expression·2026
Same journal

Mechanistic Study of the Pink1/Parkin Signaling Pathway in Mitochondrial Dysfunction and Podocyte Injury.

Critical reviews in eukaryotic gene expression·2026
Same journal

Recent Advances in CRISPR-Cas Systems for Dengue Virus Detection.

Critical reviews in eukaryotic gene expression·2026
Same journal

A Lack of Association between Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer: A Comprehensive Meta-Analysis and Power Assessment.

Critical reviews in eukaryotic gene expression·2026
Same journal

Use of Rituximab in Pediatric Nephrology: A Bibliometric and Visualization Analysis from 2003 to 2024.

Critical reviews in eukaryotic gene expression·2025
See all related articles

Gene expression in early development relies on translational control, using maternal messenger RNA (mRNA) stored as ribonucleoprotein (RNP) particles. These RNPs are activated during oocyte maturation and embryogenesis for crucial developmental events.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Gene expression regulation is critical during early development.
  • Transcriptional arrest occurs during oocyte maturation and early embryonic divisions.
  • Maternal messenger RNA (mRNA) programs early developmental events.

Purpose of the Study:

  • To elucidate the mechanisms of translational control in early development.
  • To understand the role of maternal mRNA and ribonucleoprotein (RNP) particles.
  • To identify regulatory sequences and factors involved in translational activation and repression.

Main Methods:

  • Analysis of maternal mRNA storage and translational activation.
  • Identification of cis-acting regulatory sequences in mRNA.

Related Experiment Videos

  • Investigation of proteins associated with translational regulation.
  • Study of antisense RNA involvement in translational control.

    • Main Results:

    • Maternal mRNA is stored as masked ribonucleoprotein (RNP) particles.
    • Sequence-specific translational activation of maternal mRNA occurs during oocyte maturation and embryogenesis.
    • Regulatory sequences are located in untranslated regions and downstream of coding regions.
    • Translational repression is mediated by specific cis-acting sequences and proteins.
    • Cytoplasmic polyadenylation is a key mechanism for translational activation.

    Conclusions:

    • Translational regulation is the predominant mechanism controlling gene expression in early development.
    • Maternal mRNA stored in RNP particles plays a vital role in programming embryonic development.
    • Specific regulatory elements and proteins govern mRNA translation, with cytoplasmic polyadenylation being a widespread activation mechanism.