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Related Experiment Videos

Tastes activate different second messengers in taste cells

K Miwa1, F Kanemura, K Tonosaki

  • 1Department of Oral Physiology, School of Dentistry, Asahi University, Gifu, Japan.

The Journal of Veterinary Medical Science
|January 1, 1997
PubMed
Summary

Sweet taste perception involves cyclic guanosine monophosphate (cGMP) in mouse taste cells, while bitter taste involves inositol trisphosphate (IP3). These findings support distinct molecular pathways for different taste qualities.

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Area of Science:

  • Neuroscience
  • Sensory biology
  • Molecular biology

Background:

  • Taste signal transduction occurs in the microvillous membrane of taste cells.
  • Previous hypotheses suggested cyclic guanosine monophosphate (cGMP) mediates sweet taste and inositol trisphosphate (IP3) plays a role in bitter taste transduction.
  • Distinct second messengers may be activated by different taste stimuli.

Purpose of the Study:

  • To investigate the specific second messengers involved in sweet and bitter taste transduction.
  • To test the hypotheses that cGMP mediates sweet taste and IP3 mediates bitter taste.
  • To differentiate the molecular mechanisms underlying different taste perceptions.

Main Methods:

  • Utilized radioimmunoassay measurement techniques.

Related Experiment Videos

  • Analyzed second messenger concentrations in mouse taste cells.
  • Administered sucrose and quinine to elicit taste responses.

    • Main Results:

    • Sucrose stimulation resulted in an increased concentration of cGMP in mouse taste cells.
    • Quinine stimulation led to an increased concentration of IP3 in mouse taste cells.
    • Demonstrated differential activation of second messengers by sweet and bitter stimuli.

    Conclusions:

    • The results support the hypothesis that cGMP mediates sweet taste transduction.
    • The findings support the hypothesis that IP3 mediates bitter taste transduction.
    • Different tastes activate distinct second messenger pathways in taste cells.