Related Experiment Videos
Synthesis and cholinesterase inhibitory activity of 6-, 7-methoxy-(and hydroxy-) tacrine derivatives
M R Del Giudice1, A Borioni, C Mustazza
1Laboratorio di Chimica del Farmaco, Istituto Superiore di Sanità, Roma, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|November 1, 1996
Abstract:
Some 6- and 7-methoxy-(and hydroxy-) tacrine derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. The most potent analogue in our series was the 9-heptylamino-6-methoxytacrine 3af which, in comparison with tacrine (THA), displayed an almost identical inhibitory effect, slightly lower acute toxicity and higher selectivity profile towards AchE when compared with THA.