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One pot synthesis of some new substituted hexahydro 2H-1,3-benzoxazine derivatives
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Bollettino Chimico Farmaceutico
|September 1, 1996
Abstract:
In this paper, we synthesized nineteen new compounds having 2,4-diaryl-5-oxohexahydro-2H-1,3-benzoxazine structure by the reaction of 1,3-cyclohexanedione, aromatic aldehyde and ammonium acetate. In addition, we evaluated calcium antagonistic activity of these compounds versus nicardipine.