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Related Experiment Videos

Apatite crystals in pseudoxanthoma elasticum: a combined study using electron microscopy and selected area

A Otkjaer-Nielsen, E Johnson, B Hentzer

    The Journal of Investigative Dermatology
    |October 1, 1977
    PubMed
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    This study identified calcium apatite crystals within the elastic fibers of skin affected by pseudoxanthoma elasticum. These findings clarify the composition of calcifications in this genetic skin disorder.

    Area of Science:

    • Dermatology
    • Materials Science
    • Biomineralization

    Background:

    • Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting elastic fibers.
    • Calcification of elastic fibers in PXE skin is a known characteristic.
    • The precise crystalline structure of these calcium deposits has not been fully elucidated.

    Purpose of the Study:

    • To investigate the crystalline structure and composition of calcium deposits in the elastic fibers of patients with pseudoxanthoma elasticum.
    • To characterize the mineral phase present in affected skin tissue.

    Main Methods:

    • Involved skin samples were obtained from five patients diagnosed with pseudoxanthoma elasticum.
    • Bright-field and dark-field electron microscopy were utilized for high-resolution imaging.

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  • Selected area electron diffraction was performed to determine the crystalline structure of the deposits.

    • Main Results:

    • Electron microscopy revealed distinct crystalline structures within the elastic fibers.
    • Selected area electron diffraction analysis confirmed the presence of calcium apatite crystals.
    • The findings provide specific crystallographic data on the mineral deposits in PXE.

    Conclusions:

    • The calcium deposits in the elastic fibers of pseudoxanthoma elasticum patients are composed of calcium apatite crystals.
    • This characterization contributes to understanding the pathophysiology of PXE.
    • Further research can explore the implications of calcium apatite formation in elastic tissue degeneration.