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[Peritoneal mesothelioma. A case report]

V Catania1, R Bonaccorso, F Fraggetta

  • 1Istituto di I Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi di Catania.

Annali Italiani Di Chirurgia
|September 1, 1996
PubMed
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This study details a rare case of peritoneal mesothelioma treated with cisplatin and mitomycin C chemotherapy, successfully managing side effects and improving patient survival. The findings highlight effective treatment strategies for this challenging cancer.

Area of Science:

  • Oncology
  • Medical Oncology
  • Cancer Research

Background:

  • Peritoneal mesothelioma is a rare malignancy with an incidence of 1-2 cases per million.
  • It accounts for approximately 10% of all mesothelioma cases.
  • Epidemiological links exist with asbestos exposure, and preoperative diagnosis is often challenging.

Observation:

  • A case of malignant peritoneal mesothelioma in a 61-year-old male is presented.
  • The patient underwent treatment with intraperitoneal cisplatin and intravenous mitomycin C.
  • Supportive care included GSH, prehydration, G-CSF, and erythropoietin to mitigate renal and bone marrow toxicity.

Findings:

  • The chemotherapy regimen demonstrated efficacy, leading to reduced ascites and improved patient performance status (ECOG/WHO 1) after six cycles.

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  • Intracavitary cisplatin administration resulted in rapid response with reduced systemic toxicity compared to anthracyclines, particularly beneficial for patients with cardiac involvement.
  • The patient remained alive 18 months post-laparotomy.

    • Implications:

    • Cisplatin and mitomycin C chemotherapy is a preferred option over anthracyclines for peritoneal mesothelioma, especially in patients with cardiac conditions.
    • Intracavitary chemotherapy offers a promising approach for managing peritoneal mesothelioma with potentially lower systemic toxicity.
    • Laparoscopy and laparotomy are crucial for diagnosis and initiating intracavitary therapy in peritoneal mesothelioma.