Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microvessel density in unknown primary tumors

H F Hillen1, L E Hak, S R Joosten-Achjanie

  • 1Department of Internal Medicine, University Hospital of Maastricht, The Netherlands.

International Journal of Cancer
|February 20, 1997
PubMed
Summary

Microvessel density (MVD) in liver metastases of unknown primary tumors (UPT) did not differ from known primaries. High MVD correlated with shorter survival in UPT patients, indicating its prognostic value.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors for neoplastic progression in patients with Barrett's Esophagus: a prospective cohort study.

The American journal of gastroenterology·2011
Same author

Eosinophilic oesophagitis: an enigmatic, emerging disease.

The Netherlands journal of medicine·2009
Same author

Rectal carcinoma treated with short-term preoperative radiotherapy followed by abdominoperineal resection. Significantly more presacral abscesses with absence of local recurrence.

Digestive surgery·2006
Same author

Clinical relevance of apoptotic markers in breast cancer not yet clear.

Apoptosis : an international journal on programmed cell death·2002
Same author

Education and training in internal medicine in Europe.

Postgraduate medical journal·2001
Same author

Evaluation of a method that supports pathology report coding.

Methods of information in medicine·2001

Area of Science:

  • Oncology
  • Pathology
  • Cancer Research

Background:

  • Unknown primary tumors (UPT) often present with widespread metastasis.
  • Angiogenesis, measured as microvessel density (MVD), is linked to metastasis in various solid tumors.
  • Understanding MVD in UPT liver metastases is crucial for prognostic assessment.

Purpose of the Study:

  • To compare MVD in liver metastases of UPT with known primary liver tumors (colon, breast).
  • To investigate the prognostic significance of MVD in UPT.
  • To assess the correlation between MVD and clinical factors in UPT.

Main Methods:

  • Analysis of liver metastases from 39 UPT adenocarcinomas via needle biopsy.
  • Comparison with MVD in primary colon (n=24) and breast (n=6) tumors and their metastases.

Related Experiment Videos

  • Immunocytochemistry using CD34 and von Willebrand Factor (vWF) antibodies to determine MVD.

    • Main Results:

    • No significant difference in MVD between UPT liver metastases and known primary liver metastases.
    • Primary tumors of colon and breast showed significantly higher MVD than their metastases.
    • High MVD was the sole prognostic factor for survival in univariate analysis of UPT patients.
    • Multivariate analysis identified MVD, number of metastases, tumor differentiation, and therapy as prognostic indicators.

    Conclusions:

    • MVD in liver metastases is comparable between UPT and known primaries.
    • MVD is a significant prognostic indicator for survival in UPT, with high MVD correlating to shorter survival.
    • MVD, alongside other clinical factors, aids in predicting survival outcomes for UPT patients.