Immunodiagnosis of schistosomiasis

The most efficacious and practical means of diagnosing human schistosomiasis is based on the detection of infection-specific antibodies. Because of their high sensitivity and specificity, antibody assays remain the most practical assays for epidemiologic studies and patient management. Antibody assays are particularly useful in the diagnosis of schistosomiasis in visitors from developed countries to endemic areas. These patients are often lightly infected, and tests that depend on detection of ova or circulating antigens are not reliable for these type of light and acute infections. Initial screening may be performed in the field or laboratory with the FAST-ELISA, using adult microsomal antigens. Species-specific confirmation is obtained by immunoblots with the same antigens.