Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulators of adipocyte precursor cells

S C Butterwith1

  • 1Division of Development and Reproduction, Roslin Institute (Edinburgh), Midlothian, United Kingdom.

Poultry Science
|January 1, 1997
PubMed
Summary

Understanding adipocyte hyperplasia is key for livestock growth. Growth factors, like bone morphogenetic proteins (BMPs), are crucial for adipocyte precursor cell development and differentiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.

Nature genetics·2001
Same author

Decreased muscle cell proliferation in chicks with a deletion in the GH receptor gene.

Journal of molecular endocrinology·1996
Same author

Treatment of pluripotential C3H 10T1/2 fibroblasts with bone morphogenetic protein-4 induces adipocyte commitment.

Biochemical Society transactions·1996
Same author

Preadipocyte factor-1 expression in the mouse embryo and placenta.

Biochemical Society transactions·1996
Same author

Regulation of chick muscle satellite cells by fibroblast growth factors: interaction with insulin-like growth factor-I and heparin.

Growth regulation·1995
Same author

Molecular events in adipocyte development.

Pharmacology & therapeutics·1994

Area of Science:

  • Animal Science
  • Developmental Biology
  • Cell Biology

Background:

  • Adipose tissue growth in livestock is crucial for commercial purposes.
  • Adipose tissue expands through adipocyte hypertrophy and hyperplasia.
  • While hypertrophy is understood, adipocyte hyperplasia mechanisms remain unclear.

Purpose of the Study:

  • Investigate the processes regulating adipocyte hyperplasia.
  • Identify the role of growth factors in adipocyte lineage commitment and development.
  • Utilize the chick as a model to study growth factor functions in adipogenesis.

Main Methods:

  • Focus on fibroblast-like adipocyte precursor cells, responsible for hyperplasia.
  • Examine the involvement of growth factors, including bone morphogenetic proteins (BMPs).
  • Consider autocrine-paracrine and endocrine roles of growth factors like epidermal growth factor (EGF).

Main Results:

  • Mature adipocytes have limited division capacity; precursor cells drive hyperplasia.
  • Growth factors are implicated in the commitment, proliferation, and differentiation of adipocyte precursors.
  • Specific growth factors exhibit autocrine-paracrine (e.g., those expressed in vitro) or endocrine roles (e.g., EGF).

Conclusions:

  • Adipocyte hyperplasia is driven by precursor cell proliferation and differentiation.
  • Growth factors play critical, yet poorly understood, roles in adipocyte development in vivo.
  • The chick model offers a valuable system for dissecting growth factor functions in adipogenesis.

Related Experiment Videos