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Metabolic changes during glucose tolerance tests in migraine attacks

S W Shaw, R H Johnson, H J Keogh

    Journal of the Neurological Sciences
    |August 1, 1977
    PubMed
    Summary

    Migraine attacks impair glucose tolerance, potentially due to increased lipolysis and hormonal stress responses. These metabolic changes, including elevated free fatty acids and ketones, suggest a stress state during migraine episodes.

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    Area of Science:

    • Neuroscience
    • Metabolic Medicine

    Background:

    • Migraine is a complex neurological disorder with poorly understood metabolic underpinnings.
    • Previous studies have yielded conflicting results regarding metabolic changes during migraine attacks.

    Purpose of the Study:

    • To investigate metabolic and hormonal profiles during migraine attacks compared to attack-free periods.
    • To explore the role of lipolysis and stress response in migraine pathophysiology.

    Main Methods:

    • Intravenous glucose tolerance tests were performed on 6 migraine sufferers during attacks and in attack-free periods.
    • Blood samples were analyzed for glucose, lactate, pyruvate, free fatty acids (FFA), glycerol, ketone bodies, insulin, and growth hormone.

    Main Results:

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  • Impaired glucose tolerance was observed during migraine attacks.
  • Elevated ketone bodies and FFA levels, paralleled by increased glycerol, indicated increased lipolysis.
  • Growth hormone and cortisol were elevated, while insulin was depressed during attacks.

    • Conclusions:

    • Migraine attacks are associated with increased lipolysis and a stress response pattern.
    • These metabolic and hormonal shifts may contribute to migraine pathophysiology.
    • Findings contrast with some previous studies, highlighting the need for further research.