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Apoptosis II: Apoptosis in the pathogenesis and treatment of diseases
E Moldoveanu1, A Oros, F L Hălălău
1Victor Babes Institute, Bucharest, Romania.
Abstract:
This review presents the implications of abnormal regulation of apoptosis in the pathogenesis of a variety of diseases, some of them characterized by a failure of cells to undergo apoptosis, and the others characterized by cell loss. The new perspectives in the therapy of such diseases by developing therapeutic agents that increase or decrease the susceptibility of particular cells to apoptosis are also reviewed.
Insights
Abnormal apoptosis regulation contributes to various diseases by either preventing cell death or causing excessive cell loss. Therapeutic strategies targeting apoptosis offer new treatment perspectives for these conditions.
Area of Science:
- Cell Biology
- Pathogenesis
- Disease Mechanisms
Background:
- Apoptosis, or programmed cell death, is a critical biological process.
- Dysregulation of apoptosis is implicated in numerous human diseases.
- Diseases arise from either insufficient or excessive apoptotic cell death.
Purpose of the Study:
- To review the role of aberrant apoptosis in disease pathogenesis.
- To explore novel therapeutic strategies targeting apoptosis.
- To discuss agents that modulate cellular apoptosis susceptibility.
Main Methods:
- Literature review of apoptosis and disease.
- Analysis of pathogenetic mechanisms linked to apoptosis.
- Synthesis of current and emerging therapeutic approaches.
Main Results:
- Abnormal apoptosis underlies diseases with cell accumulation (e.g., cancer) and cell loss (e.g., neurodegeneration).
- Therapeutic agents can be developed to either induce or inhibit apoptosis.
- Targeting apoptosis offers a promising avenue for disease treatment.
Conclusions:
- Aberrant apoptosis is a key factor in diverse pathologies.
- Modulating apoptosis presents a viable therapeutic strategy.
- Further research into apoptosis regulation can yield novel treatments.