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Related Experiment Videos

Mouse strain differences in ozone dosimetry and body temperature changes

R Slade1, W P Watkinson, G E Hatch

  • 1Pulmonary Toxicology Branch, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

The American Journal of Physiology
|January 1, 1997
PubMed
Summary

Differences in mouse strain susceptibility to ozone (O3) may stem from varying O3 doses delivered to the lungs. C3 mice received less O3 and showed greater body temperature drops, suggesting a link between metabolism and O3 exposure.

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Area of Science:

  • Environmental Health
  • Toxicology
  • Animal Models

Background:

  • Strain-specific differences in susceptibility to inhaled ozone (O3) are documented in mice.
  • C57BL/6J (B6) mice are generally more sensitive to O3 than C3H/HEJ (C3) mice.

Purpose of the Study:

  • To investigate if differing O3 doses delivered to the lungs explain observed strain differences in O3 susceptibility.
  • To correlate lung O3 dose with changes in basal metabolism, indicated by body core temperature.

Main Methods:

  • Mice of C3 and B6 strains were exposed to 18O-labeled ozone (18O3).
  • 18O concentrations in pulmonary tissues were measured to quantify O3 dose.
  • Body core temperatures (Tco) were monitored using implanted probes during O3 exposure.

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Main Results:

  • C3 mice exhibited significantly lower 18O concentrations in lungs (46% less) and tracheas (61% less) compared to B6 mice.
  • Both strains showed decreased Tco, but C3 mice experienced a 70% greater mean temperature x time product decrease.
  • Nasal 18O levels were lower in C3 mice, though not statistically significant.

Conclusions:

  • Observed strain differences in O3 susceptibility may be attributed to variations in the O3 dose delivered to the lung.
  • Differences in the ability to lower body core temperature in response to O3 exposure might influence O3 dose and subsequent susceptibility.