Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anisotropic repolarization in ventricular tissue

M Gotoh1, T Uchida, W Fan

  • 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

The American Journal of Physiology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis.

Clinical and experimental immunology·2019
Same author

Synergism between Enhanced Late Inward Currents and Tissue Fibrosis in the Initiation of Spontaneous Ventricular Tachyarrhythmias.

Journal of heart health·2016
Same author

The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Pathology of internal mammary arteries used as bypass grafts.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Interstitial lung disease in patients with hepatopulmonary syndrome: a case series and new observations.

Lung·2014
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Myocardial fiber orientation significantly impacts ventricular cell repolarization. Action potential duration changes with activation sequence when propagation is transverse to fibers, but not when parallel.

Area of Science:

  • Cardiovascular Physiology
  • Electrophysiology
  • Biophysics

Background:

  • Extracellular recording and stimulation reveal activation sequence influences ventricular cell refractory periods.
  • The role of myocardial fiber orientation in cardiac repolarization remains unclear.

Purpose of the Study:

  • To investigate the impact of myocardial fiber orientation on the cardiac repolarization process.
  • To determine if fiber direction affects action potential duration and effective refractory periods.

Main Methods:

  • Studied 12 pig right ventricular tissue blocks (30x30x2 mm) in vitro.
  • Recorded transmembrane action potentials and measured effective refractory periods.
  • Paced tissues at 500- and 1,000-ms cycle lengths, recording at varying distances along and across fiber orientations.

Related Experiment Videos

Main Results:

  • Depolarization propagation was slower across fibers (transverse) than along fibers (longitudinal).
  • In the transverse direction, action potential duration shortened with increased distance from stimulation (P < 0.001).
  • Action potential duration remained consistent in the longitudinal direction regardless of distance.

Conclusions:

  • Myocardial fiber orientation significantly influences cardiac repolarization.
  • Activation sequence affects action potential duration when propagation is transverse to myocardial fibers.
  • Activation propagation parallel to fiber orientation shows minimal change in action potential duration.