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Rifampicin-induced immune thrombocytopenia
Y S Mehta1, F F Jijina, S S Badakere
1Institute of Immunohematology (ICMR), KEM Hospital Campus, Parel, Bombay, India.
Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|December 1, 1996
Summary
Rifampicin can cause low platelet counts (thrombocytopenia) in tuberculosis patients due to drug-dependent antiplatelet antibodies. These antibodies bind platelets more strongly in the presence of rifampicin, confirming the drug
Area of Science:
- Immunology
- Pharmacology
- Hematology
Background:
- Pulmonary tuberculosis treatment often involves rifampicin.
- Thrombocytopenia is a potential adverse drug reaction.
- Prior rifampicin exposure was noted in affected patients.