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Biochemical alterations in paromomycin-treated Leishmania donovani promastigotes
M Maarouf1, F Lawrence, S Brown
1Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France.
Parasitology Research
|January 1, 1997
Abstract:
Paromomycin is used for the treatment of leishmaniasis in humans, but little is known about its mechanism of action. Investigating the effect of this antibiotic on promastigotes of Leishmania donovani, we showed that inhibition of the multiplication of these parasites could be related to its effect on RNA synthesis and to modifications of membranous polar lipids and membrane fluidity, leading to altered membrane permeability.