Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MHC class I and class II structures

E Y Jones1

  • 1Laboratory of Molecular Biophysics, The Rex Richards Building, South Parks Road, Oxford OX1 3QU, UK. yvon@biop.ox.ac.uk

Current Opinion in Immunology
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes.

Vitamins and hormones·2009
Same author

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

Acta crystallographica. Section D, Biological crystallography·2006
Same author

Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2004
Same author

HLA-B27 and disease pathogenesis: new structural and functional insights.

Expert reviews in molecular medicine·2003
Same author

The human low affinity Fcgamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties.

The Journal of biological chemistry·2001
Same author

Gene polymorphism in Netherton and common atopic disease.

Nature genetics·2001
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Structural biology advances reveal detailed peptide binding mechanisms for Major Histocompatibility Complex (MHC) class I and class II molecules, enhancing understanding of immune response.

Area of Science:

  • Immunology
  • Structural Biology
  • Molecular Biology

Background:

  • The fundamental structures of Major Histocompatibility Complex (MHC) class I and class II molecules are well-understood.
  • Recent advancements have focused on the detailed structural aspects of these crucial immune system components.

Purpose of the Study:

  • To elucidate the detailed structural mechanisms of peptide binding in MHC class I and class II molecules.
  • To provide insights into the molecular interactions governing antigen presentation.

Main Methods:

  • Analysis of recent structural data for MHC class I and class II molecules.
  • Examination of peptide binding grooves and associated molecular mechanisms.

Main Results:

Related Experiment Videos

  • Detailed structural data on MHC class I alleles reveal specifics of the peptide binding groove.
  • Elucidation of mechanisms enabling the binding of diverse peptides to MHC class I.
  • Recent MHC class II structures illustrate peptide binding modes in mature complexes and during maturation with CLIP.

    • Conclusions:

    • Structural insights into MHC class I and II molecules have significantly advanced our understanding of peptide binding.
    • These findings are critical for comprehending adaptive immune responses and developing targeted therapies.