Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regionalization in the mammalian telencephalon

G Fishell1

  • 1Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 11217, USA. fishell@saturn.med.nyu.edu

Current Opinion in Neurobiology
|February 1, 1997
PubMed
Summary

Telencephalon regionalization creates distinct brain areas late in development. Transplantation experiments investigate how telencephalic cells commit to specific regional identities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.

Nature·2014
Same author

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.

Gene expression patterns : GEP·2011
Same author

Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain.

Nature neuroscience·2001
Same author

In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.

Development (Cambridge, England)·2001
Same author

Telencephalic neural progenitors appear to be restricted to regional and glial fates before the onset of neurogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.

Development (Cambridge, England)·2001

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • The telencephalon, the largest part of the brain, undergoes regionalization to form distinct functional and anatomical territories.
  • Previous studies using cell fate analysis and gene expression suggest telencephalic regionalization occurs later in development than in the spinal cord or hindbrain.

Purpose of the Study:

  • To investigate the mechanisms driving the commitment of telencephalic cells to specific regional identities.
  • To understand the developmental processes underlying brain regionalization.

Main Methods:

  • Utilizing transplantation experiments to track cell‌های fate and regional identity.
  • Employing cell fate analysis and gene expression profiling.

Main Results:

Related Experiment Videos

  • Transplantation experiments provide insights into the timing and mechanisms of cell commitment.
  • Gene expression patterns reveal molecular cues involved in regional identity specification.

Conclusions:

  • Cellular commitment to regional identity in the telencephalon is a complex process.
  • Transplantation studies are crucial for deciphering the mechanisms of developmental neurobiology and brain regionalization.