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Evolutionary adaptability of biological macromolecules

M Conrad

    Journal of Molecular Evolution
    |September 20, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Protein evolution depends on how gradually structure and function change with genetic mutations. This gradualism influences protein properties and the role of neutral changes in evolution.

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    Redox biology·2017

    Area of Science:

    • Biochemistry
    • Evolutionary Biology
    • Structural Biology

    Background:

    • Protein structure and function are critical for biological processes.
    • Evolutionary changes in proteins are driven by alterations in their primary amino acid sequence.
    • The relationship between primary sequence changes and subsequent tertiary structure/function modifications is complex.

    Purpose of the Study:

    • To investigate the degree of gradualism in protein evolution.
    • To explore how stepwise changes in primary protein structure influence tertiary structure and function.
    • To understand the implications of this gradualism for protein properties and evolutionary theory.

    Main Methods:

    • Analysis of protein primary and tertiary structure relationships.

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  • Theoretical modeling of protein evolution under gradual change.
  • Examination of the role of weak bonding in protein structure stability.

    • Main Results:

    • The degree of gradualism in protein evolution is a fundamental aspect, acting as both a prerequisite and outcome of evolutionary processes.
    • Selection acts on this degree of gradualism, shaping protein characteristics.
    • Neutral evolutionary phenomena have a nuanced significance when considered alongside selection pressures.

    Conclusions:

    • The gradual nature of protein evolution is intrinsically linked to evolutionary mechanisms.
    • Understanding gradualism is key to comprehending modern protein structure-function relationships.
    • The interplay between gradualism, selection, and neutral drift shapes the landscape of protein evolution.