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Intra-aneurysmal GDC embolization followed by intrathecal tPA administration for poor-grade basilar tip aneurysm
M Ezura1, A Takahashi, K Ogasawara
1Department of Intravascular Neurosurgery, Kohnan Hospital, Sendai, Japan.
Background:
This 42-year-old male presented with subarachnoid hemorrhage of Hunt and Kosnik Grade IV, complicated by neurogenic pulmonary edema, prolongation of the electrocardiographic Q-Q interval, and acute renal failure.
Methods:
Surgical clipping was not indicated, so intra-aneurysmal embolization using Guglielmi detachable coils (GDCs) was performed followed by intrathecal infusion of tissue-type plasminogen activator (tPA) via spinal drainage.
Results:
The patient made a complete recovery 2 1/2 months later except for partial third cranial nerve palsy.
Conclusions:
Intra-aneurysmal GDC embolization followed by intrathecal tPA via spinal drainage is an excellent method for treating aneurysms that are difficult to treat surgically.