Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparison of the cervical cytology test using the PAPNET method and conventional microscopy

D Weissbrod1, M Torres, A Rodríguez

  • 1National Institute of Epidemiologic Diagnosis and Reference (Instituto Nacional de Diagnóstico y Referencia Epidemiológicos-INDRE), Mexico City, Mexico.

Bulletin of the Pan American Health Organization
|December 1, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histopathologic prognostic score in colorectal adenocarcinomas.

Anticancer research·1998
Same author

Earlier onset of Alzheimer's disease in men with Down syndrome.

Neurology·1998
Same author

Molecular prophets of death in the fly.

American journal of human genetics·1998
Same author

Is the high level of nitric oxide metabolites a marker in early rejection after experimental islet pancreas transplantation?

Transplantation proceedings·1998
Same author

Structure of the human CD94 C-type lectin gene.

Immunogenetics·1998
Same author

Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma.

Blood·1998

Mexican Pap smear diagnoses show poor agreement between state labs and national review, and automated systems. Improving quality control and training is crucial for early cervical cancer detection.

Area of Science:

  • Gynecologic Pathology
  • Cytopathology
  • Public Health Diagnostics

Background:

  • Cervical cancer screening relies on accurate Pap test interpretation.
  • Quality assurance is essential for reliable diagnostic services.

Purpose of the Study:

  • To evaluate the diagnostic agreement of Pap test slides between Mexican state laboratories, national reference (INDRE), and the automated PAPNET system.
  • To identify discrepancies in cervical cytology diagnoses and their implications for patient care.

Main Methods:

  • 10,098 Pap test slides were reexamined by conventional methods at INDRE and by the PAPNET system.
  • Kappa correlation coefficients were calculated to assess inter-observer agreement.

Main Results:

Keywords:
AmericasBiologyCancerCervical Cancer--prevention and controlComparative StudiesCytologyDeveloping CountriesDiseasesExaminations And DiagnosesLaboratory Examinations And DiagnosesLatin AmericaMexicoNeoplasmsNorth AmericaResearch MethodologyResearch ReportScreeningStudies

Related Experiment Videos

  • Agreement between state labs and INDRE was moderate (Kappa=0.62), with poorest agreement in distinguishing degrees of dysplasia.
  • PAPNET showed better agreement with INDRE (Kappa=0.80) but had limited ability to differentiate pathologies and high false-negative rates.
  • Underestimation of mild to severe dysplasia by state labs (12-20%) is concerning for preventative care.

Conclusions:

  • There is a significant need to enhance the quality of cervical cytology diagnoses in Mexican state public health laboratories through improved training and supervision.
  • The PAPNET system presents challenges in differentiating pathological alterations and requires methods to detect and review false negatives before widespread adoption.