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Pulmonary tuberculosis associated with invasive pseudallescheriasis
J Tekavec1, E Mlinarić-Missoni, V Babic-Vazic
1Hospital for Lung Diseases, Klenovnik, Croatia.
Chest
|February 1, 1997
Summary
A woman with tuberculosis developed a rare fungal pneumonia caused by Scedosporium apiospermum. Treatment with antifungal medications and tuberculosis drugs led to remission of both infections.
Area of Science:
- Mycology
- Infectious Diseases
- Pulmonology
Background:
- Pulmonary tuberculosis is a significant global health concern.
- Fungal pneumonias can present as opportunistic infections, particularly in immunocompromised individuals.
Observation:
- A 54-year-old immunocompetent woman with pulmonary tuberculosis developed pneumonia.
- Scedosporium apiospermum (Pseudallescheria boydii) and Mycobacterium tuberculosis were identified in bronchoalveolar lavage fluid.
- The patient had occupational exposure to fungal conidia from cleaning swimming pools.
Findings:
- Successful treatment of invasive pulmonary pseudallescheriasis and tuberculosis was achieved.
- Combination therapy included antituberculosis drugs, miconazole nitrate, and ketoconazole.
- The patient experienced remission of her pulmonary infection.
Implications:
- This case highlights an unusual co-infection of pulmonary tuberculosis and Scedosporium apiospermum pneumonia.
- It underscores the importance of considering fungal infections in patients with tuberculosis, even in immunocompetent individuals.
- Successful management with a combination of antifungal and antitubercular therapy is demonstrated.