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Delayed hypersensitivity to flurbiprofen

A Romano¹, F Pietrantonio

¹Istituto di Medicina Interna e Geriatria. Università Cattolica del Sacro Cuore, Rome, Italy.

Journal of Internal Medicine

|January 1, 1997

Summary

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True allergy to flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), is rare. This case study documents a patient experiencing a severe reaction, suggesting a delayed hypersensitivity response confirmed by patch testing.

Area of Science:

Immunology
Dermatology
Pharmacology

Background:

Immune-mediated reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are uncommon.
True drug allergy to flurbiprofen has not been previously documented in scientific literature.

Observation:

A patient presented with a maculopapular rash 48 hours after initiating oral flurbiprofen.
The patient subsequently developed angioedema and hypotension two days after the rash onset.

Findings:

Patch testing with flurbiprofen yielded positive results at both 48 and 72 hours post-application.
The clinical presentation and allergologic findings strongly indicate a type IV hypersensitivity reaction.

Implications:

This case suggests that flurbiprofen can induce delayed-type hypersensitivity reactions.

Related Experiment Videos

Patch testing with NSAIDs is a valuable diagnostic tool for confirming delayed hypersensitivity to these medications.

Further investigation into NSAID-induced hypersensitivity is warranted.