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Neonatal Torulopsis glabrata fungemia

J D Reich1, K Huddleston, D Jorgensen

  • 1Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga. 30303, USA.

Southern Medical Journal
|February 1, 1997
PubMed

Insights

Torulopsis glabrata fungemia is a rare but serious opportunistic infection in premature infants. Early treatment with amphotericin B and reducing risk factors can improve outcomes.

Area of Science:

  • Mycology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Torulopsis glabrata is an opportunistic fungal pathogen.
  • Infections in neonates are rare, with only four reported cases prior to this study.

Observation:

  • Two cases of fungemia caused by Torulopsis glabrata in premature infants are presented.
  • Both infants had received surfactant, artificial ventilation, intravascular catheters, broad-spectrum antibiotics, and hyperalimentation.
  • One infant survived the fungal infection but later died of bacterial sepsis.

Findings:

  • Torulopsis glabrata fungemia is associated with significant iatrogenic risk factors in premature infants.
  • The organism is susceptible to amphotericin B and 5-fluorocytosine.
  • Resistance to fluconazole and reduced susceptibility to other azoles (ketoconazole, clotrimazole, itraconazole) were noted compared to Candida albicans.

Implications:

  • Reducing iatrogenic risk factors is crucial for preventing Torulopsis glabrata fungemia.
  • Initial treatment should involve amphotericin B, with 5-fluorocytosine as a potential addition.
  • Further research into the pathogenesis and optimal management of Torulopsis glabrata infections in neonates is warranted.

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