Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel electrode designs for electrochemotherapy

R A Gilbert1, M J Jaroszeski, R Heller

  • 1Department of Chemical Engineering, University of South Florida, Tampa 33612-4799, USA.

Biochimica Et Biophysica Acta
|February 11, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Nuclear Modifications of B^{+} Meson Production in p-Pb Collisions at sqrt[s_{NN}]=8.16  TeV.

Physical review letters·2025
Same author

A comparative study of target fabrication strategies for microgram muonic atom spectroscopy.

Scientific reports·2025
Same author

Search for New Resonances Decaying to Pairs of Merged Diphotons in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2025
Same author

Searches for Pair-Produced Multijet Resonances Using Data Scouting in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2024
Same author

Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 TeV.

Physical review letters·2024
Same author

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2024

Novel electrode designs for electrochemotherapy show promise. A 2x2 needle array design significantly improved melanoma tumor treatment in mice compared to standard parallel plate electrodes.

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Medical Devices

Background:

  • Electrochemotherapy (ECT) utilizes electrical pulses to enhance drug delivery for cancer treatment.
  • Standard ECT employs parallel plate electrodes, achieving high response rates (70-85%) in preclinical and clinical settings.
  • Limitations exist for parallel plate electrodes in certain tumor locations or types.

Purpose of the Study:

  • To develop and evaluate novel electrode designs for electrochemotherapy.
  • To compare the efficacy of new designs against the standard parallel plate electrode for melanoma treatment in mice.

Main Methods:

  • Five novel electrode configurations were designed and fabricated.
  • The effectiveness of each design, including a 2x2 needle array, was tested against parallel plate electrodes.

Related Experiment Videos

  • Melanoma tumor-bearing mice were treated, and outcomes such as tumor doubling time and complete response rate were assessed.

    • Main Results:

    • The 2x2 needle array electrode design demonstrated a 50% increase in tumor doubling time compared to parallel plate electrodes.
    • The 2x2 needle array also showed a 50% improvement in complete response rate.
    • Other novel designs were also evaluated, with varying degrees of efficacy.

    Conclusions:

    • Novel electrode designs offer potential improvements over standard parallel plate electrodes for electrochemotherapy.
    • The 2x2 needle array design is a promising alternative for treating melanoma, warranting further investigation.
    • Further research into optimized electrode configurations could enhance electrochemotherapy outcomes.