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The differentiation antigen Ly-6E.1 is expressed in mouse metastatic tumor cell lines
M A Cohn1, D Kramerov, E F Hulgaard
1Danish Cancer Society, Department of Molecular Cancer Biology, Copenhagen. cohn@biobase.dk
FEBS Letters
|February 17, 1997
Abstract:
We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly metastatic mouse adenocarcinoma cell line CSML-100 by differential display. The expression is specific for the metastatic cell line as the closely related, non-metastatic mouse adenocarcinoma cell line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour cell lines, exclusively metastatic ones. To date, active Ly-6A/E has only been described in lymphoid cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.