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Conservative surgery for infiltrating lobular breast carcinoma
B Salvadori1, E Biganzoli, P Veronesi
1Istituto di Statistica Medica e Biometria, Università degli Study di Milano, Italy.
The British Journal of Surgery
|January 1, 1997
Summary
Conservative surgery is safe for both infiltrating lobular carcinoma (ILC) and infiltrating ductal carcinoma (IDC) breast cancer patients. Studies show no increased risk of local recurrence for ILC compared to IDC when treated conservatively.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- Reports suggest infiltrating lobular carcinoma (ILC) may have a high risk of local recurrence with conservative breast cancer treatment.
- This study addresses concerns regarding the safety of conservative methods for ILC compared to infiltrating ductal carcinoma (IDC).
Purpose of the Study:
- To compare the risk of intrabreast relapse in conservatively treated ILC versus IDC patients.
- To evaluate the oncological safety of breast-conserving surgery for different types of invasive breast carcinoma.
Main Methods:
- A comparative study of 286 ILC patients and 1903 IDC patients treated between 1973-1989.
- All patients underwent quadrantectomy, axillary dissection, and radiotherapy, with adjuvant therapy based on nodal and menopausal status.
- Long-term follow-up (median 133-137 months) and histology review were conducted.
Main Results:
- No significant difference in the cumulative local recurrence rate was observed between ILC and IDC groups at 10 years (approximately 7%).
- Histological review identified minor differences in multifocality and extensive intraductal components between ILC and IDC.
Conclusions:
- Conservative breast surgery is an equally safe treatment option for both infiltrating lobular carcinoma and infiltrating ductal carcinoma.
- The findings support the use of breast-conserving approaches for a wider range of early-stage breast cancer types.